5/6/2025
Last update
5/6/2025
Reviewed By
Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8.8
USERS' SCORE
Good
Based on 6 Reviews
8.1
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Oregano Oil (Origanum vulgare) min. 55% Carvacrol)
0.2 ml / 181 mg
**
Ginger Oil (Zingiber officinale)
0.02 ml / 17.6 mg
**
Fennel Oil (Foeniculum vulgare)
0.02 ml / 19.3 mg
**
Top Medical Research Studies
9.5
We evaluated the protective effects of oregano (Origanum vulgare) on liver toxicity induced by cyclophosphamide, a commonly used chemotherapy drug known for its potential liver damage. In our study, we pre-treated mice with various doses of oregano extract for seven days before administering a chemotherapy dose.
After 24 hours, we collected blood samples and liver tissues from the animals to assess the liver's response. The results were promising: we found that serum markers indicating liver damage, such as ALT, AST, and ALP, were significantly elevated in the mice treated with cyclophosphamide alone. However, those receiving oregano extract showed a marked reduction in these markers, suggesting that oregano may help protect the liver from poisoning caused by chemotherapy.
The histological examinations aligned with these findings and confirmed that oregano extract has protective properties against liver damage. With its rich array of flavonoids and phenolic compounds, oregano seems capable of supporting liver health during challenging treatments. Thus, incorporating oregano may offer a supportive approach to mitigate the side effects of chemotherapy on the liver.
After 24 hours, we collected blood samples and liver tissues from the animals to assess the liver's response. The results were promising: we found that serum markers indicating liver damage, such as ALT, AST, and ALP, were significantly elevated in the mice treated with cyclophosphamide alone. However, those receiving oregano extract showed a marked reduction in these markers, suggesting that oregano may help protect the liver from poisoning caused by chemotherapy.
The histological examinations aligned with these findings and confirmed that oregano extract has protective properties against liver damage. With its rich array of flavonoids and phenolic compounds, oregano seems capable of supporting liver health during challenging treatments. Thus, incorporating oregano may offer a supportive approach to mitigate the side effects of chemotherapy on the liver.
Read More
9
We explored the effects of a natural flavone, didymin, derived from oregano (Origanum vulgare), on liver health. Our research aimed to understand how didymin can help prevent liver damage, specifically in cases induced by carbon tetrachloride (CCl), a commonly used chemical that can harm the liver.
In our study, we found that didymin significantly reduced indicators of liver injury in mice, including levels of important liver enzymes like ALT and AST. Furthermore, treatment with didymin led to lower levels of toxic substances and inflammatory markers in the liver, while boosting the activity of antioxidant enzymes that protect the liver from damage.
We also observed that didymin effectively inhibited key signaling pathways involved in inflammation, specifically the NF-κB and MAPK pathways. Impressively, didymin increased the expression of a protein known as RKIP, which plays a critical role in protecting liver cells. It was interesting to note that when we inhibited RKIP specifically, the protective effects of didymin were diminished.
Overall, our findings suggest that didymin from oregano holds promise in alleviating liver injury, primarily through its antioxidant properties and its ability to regulate inflammatory responses in the liver.
In our study, we found that didymin significantly reduced indicators of liver injury in mice, including levels of important liver enzymes like ALT and AST. Furthermore, treatment with didymin led to lower levels of toxic substances and inflammatory markers in the liver, while boosting the activity of antioxidant enzymes that protect the liver from damage.
We also observed that didymin effectively inhibited key signaling pathways involved in inflammation, specifically the NF-κB and MAPK pathways. Impressively, didymin increased the expression of a protein known as RKIP, which plays a critical role in protecting liver cells. It was interesting to note that when we inhibited RKIP specifically, the protective effects of didymin were diminished.
Overall, our findings suggest that didymin from oregano holds promise in alleviating liver injury, primarily through its antioxidant properties and its ability to regulate inflammatory responses in the liver.
Read More
9.5
In our exploration of oregano's beneficial effects on liver health, we conducted a study on Wistar rats to assess how an extract from Origanum vulgare could shield against liver damage caused by carbon tetrachloride (CCl4). The experiment was structured with various groups of rats: a control group, a group receiving only the oregano extract, and others treated with CCl4 alongside different doses of oregano over 15 days.
Throughout the study, we measured key indicators of liver function, including enzymes in the serum, the levels of lipid peroxides, and antioxidant markers in liver tissues. We found that CCl4 led to clear signs of liver injury, but the administration of oregano extract showed significant protective effects. This improvement was most pronounced at the highest dose of 150 mg/kg.
Our analyses revealed that oregano not only helped in reducing liver enzyme levels indicative of damage but also boosted antioxidant activity in the liver. Histopathological examinations aligned with these biochemical improvements, indicating healthier liver cells after treatment with oregano. This study suggests that oregano could be a valuable ally in protecting against liver toxicity.
Throughout the study, we measured key indicators of liver function, including enzymes in the serum, the levels of lipid peroxides, and antioxidant markers in liver tissues. We found that CCl4 led to clear signs of liver injury, but the administration of oregano extract showed significant protective effects. This improvement was most pronounced at the highest dose of 150 mg/kg.
Our analyses revealed that oregano not only helped in reducing liver enzyme levels indicative of damage but also boosted antioxidant activity in the liver. Histopathological examinations aligned with these biochemical improvements, indicating healthier liver cells after treatment with oregano. This study suggests that oregano could be a valuable ally in protecting against liver toxicity.
Read More
Most Useful Reviews
9
Restores bilirubin levels
7 people found this helpful
Oregano oil is a natural antibiotic with anti-inflammatory, antiviral, and antibacterial benefits. Regular consumption promotes liver cell regeneration. After three months of taking it alongside sunflower lecithin, my bilirubin levels returned to normal. I highly recommend this product!
Read More
6
Alleviates SIBO symptoms
4 people found this helpful
Oregano oil has significantly helped with my SIBO and discomfort from excess intestinal gas. Initially, it caused slight dizziness and headaches, which I understand is due to toxins being eliminated from the body. To aid this, I took NAC and silymarin to support liver function. This combination worked wonders for me!
Read More
7.5
Supports cold relief
3 people found this helpful
These oregano oil capsules are fantastic! They help prevent colds and have alleviated my dermagraphism by supporting liver health. I appreciate the enteric coating and the reasonable price.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8.8
- All Researches
9.5
We evaluated the protective effects of oregano (Origanum vulgare) on liver toxicity induced by cyclophosphamide, a commonly used chemotherapy drug known for its potential liver damage. In our study, we pre-treated mice with various doses of oregano extract for seven days before administering a chemotherapy dose.
After 24 hours, we collected blood samples and liver tissues from the animals to assess the liver's response. The results were promising: we found that serum markers indicating liver damage, such as ALT, AST, and ALP, were significantly elevated in the mice treated with cyclophosphamide alone. However, those receiving oregano extract showed a marked reduction in these markers, suggesting that oregano may help protect the liver from poisoning caused by chemotherapy.
The histological examinations aligned with these findings and confirmed that oregano extract has protective properties against liver damage. With its rich array of flavonoids and phenolic compounds, oregano seems capable of supporting liver health during challenging treatments. Thus, incorporating oregano may offer a supportive approach to mitigate the side effects of chemotherapy on the liver.
After 24 hours, we collected blood samples and liver tissues from the animals to assess the liver's response. The results were promising: we found that serum markers indicating liver damage, such as ALT, AST, and ALP, were significantly elevated in the mice treated with cyclophosphamide alone. However, those receiving oregano extract showed a marked reduction in these markers, suggesting that oregano may help protect the liver from poisoning caused by chemotherapy.
The histological examinations aligned with these findings and confirmed that oregano extract has protective properties against liver damage. With its rich array of flavonoids and phenolic compounds, oregano seems capable of supporting liver health during challenging treatments. Thus, incorporating oregano may offer a supportive approach to mitigate the side effects of chemotherapy on the liver.
Read More
9.5
In our exploration of oregano's beneficial effects on liver health, we conducted a study on Wistar rats to assess how an extract from Origanum vulgare could shield against liver damage caused by carbon tetrachloride (CCl4). The experiment was structured with various groups of rats: a control group, a group receiving only the oregano extract, and others treated with CCl4 alongside different doses of oregano over 15 days.
Throughout the study, we measured key indicators of liver function, including enzymes in the serum, the levels of lipid peroxides, and antioxidant markers in liver tissues. We found that CCl4 led to clear signs of liver injury, but the administration of oregano extract showed significant protective effects. This improvement was most pronounced at the highest dose of 150 mg/kg.
Our analyses revealed that oregano not only helped in reducing liver enzyme levels indicative of damage but also boosted antioxidant activity in the liver. Histopathological examinations aligned with these biochemical improvements, indicating healthier liver cells after treatment with oregano. This study suggests that oregano could be a valuable ally in protecting against liver toxicity.
Throughout the study, we measured key indicators of liver function, including enzymes in the serum, the levels of lipid peroxides, and antioxidant markers in liver tissues. We found that CCl4 led to clear signs of liver injury, but the administration of oregano extract showed significant protective effects. This improvement was most pronounced at the highest dose of 150 mg/kg.
Our analyses revealed that oregano not only helped in reducing liver enzyme levels indicative of damage but also boosted antioxidant activity in the liver. Histopathological examinations aligned with these biochemical improvements, indicating healthier liver cells after treatment with oregano. This study suggests that oregano could be a valuable ally in protecting against liver toxicity.
Read More
9
We evaluated how oregano seed extract, specifically its ethyl acetate fraction, affects liver health in mice that were fed a high-fat diet. Over a period of 10 weeks, we found that when these mice were given 100 mg/kg of oregano seed extract alongside their high-fat diet, their weight and various liver enzyme levels significantly improved.
Remarkably, we observed a reduction in harmful substances like cholesterol and triglycerides, alongside an increase in beneficial high-density lipoprotein. This indicates a positive shift in the mice's overall liver health. Additionally, the fat accumulation in the liver decreased notably, which is a key factor in non-alcoholic fatty liver disease.
Furthermore, we examined the expression of certain genes related to fat metabolism and discovered that their activity went down significantly in the mice that received oregano treatment. This suggests that oregano may help regulate how the body processes fats, potentially leading to better management of obesity and fat-related liver issues.
Remarkably, we observed a reduction in harmful substances like cholesterol and triglycerides, alongside an increase in beneficial high-density lipoprotein. This indicates a positive shift in the mice's overall liver health. Additionally, the fat accumulation in the liver decreased notably, which is a key factor in non-alcoholic fatty liver disease.
Furthermore, we examined the expression of certain genes related to fat metabolism and discovered that their activity went down significantly in the mice that received oregano treatment. This suggests that oregano may help regulate how the body processes fats, potentially leading to better management of obesity and fat-related liver issues.
Read More
9
Oregano may protect liver health
We explored the impact of essential oils, specifically oregano, on liver health in dairy calves affected by trichothecenes from Fusarium sporotrichioides. In this study, we divided twelve calves into two groups: one receiving a blend of essential oils (including oregano) and the other as a control. Over 40 days, we monitored their growth, blood health, and overall wellness while ensuring both groups consumed feed contaminated with trichothecenes.
The calves that received essential oils showed a positive trend in body weight compared to the control group. We observed notable improvements in their blood parameters, including higher leukocyte counts and lower levels of certain liver enzymes, suggesting that oregano may help reduce liver stress. This group also exhibited lower oxidative stress markers and reduced inflammation as indicated by lower serum levels of haptoglobin and C-reactive protein.
In contrast, the control group displayed signs of liver stress and inflammation upon analysis. Our findings indicate that oregano, alongside other essential oils, could mitigate the negative effects of trichothecenes on liver health in calves, serving as a potential aid in improving overall animal wellbeing and health resilience.
The calves that received essential oils showed a positive trend in body weight compared to the control group. We observed notable improvements in their blood parameters, including higher leukocyte counts and lower levels of certain liver enzymes, suggesting that oregano may help reduce liver stress. This group also exhibited lower oxidative stress markers and reduced inflammation as indicated by lower serum levels of haptoglobin and C-reactive protein.
In contrast, the control group displayed signs of liver stress and inflammation upon analysis. Our findings indicate that oregano, alongside other essential oils, could mitigate the negative effects of trichothecenes on liver health in calves, serving as a potential aid in improving overall animal wellbeing and health resilience.
Read More
9
In our exploration of the effects of oregano (Origanum vulgare) on liver health, we conducted a thorough study using rats to assess its potential as a treatment for hepatic encephalopathy (HE). This condition is often linked with chronic liver disease and can lead to a decline in brain function due to elevated ammonia levels.
We analyzed the chemical makeup of oregano's hexane extract, identifying 25 different compounds, with prominent elements like cholesten-3-one and gamma-tocopherol. To test its effectiveness, we divided the rats into seven groups: a control group, groups receiving different doses of oregano, and groups treated with thioacetamide (TAA), which induces HE.
Throughout the study, we measured various outcomes, including behavior changes, body weight, and blood markers. TAA caused anxiety and cognitive impairments in the rats, alongside significant weight changes and liver stress. Remarkably, treatment with oregano significantly improved these symptoms, showcasing its potential as a hepato- and neuroprotective agent.
We found that oregano’s protective effects were comparable to those of silymarin, a standard liver treatment. Both treatments helped mitigate the damaging effects of TAA on the liver and brain, suggesting that oregano could be an excellent alternative in supporting liver health and function.
We analyzed the chemical makeup of oregano's hexane extract, identifying 25 different compounds, with prominent elements like cholesten-3-one and gamma-tocopherol. To test its effectiveness, we divided the rats into seven groups: a control group, groups receiving different doses of oregano, and groups treated with thioacetamide (TAA), which induces HE.
Throughout the study, we measured various outcomes, including behavior changes, body weight, and blood markers. TAA caused anxiety and cognitive impairments in the rats, alongside significant weight changes and liver stress. Remarkably, treatment with oregano significantly improved these symptoms, showcasing its potential as a hepato- and neuroprotective agent.
We found that oregano’s protective effects were comparable to those of silymarin, a standard liver treatment. Both treatments helped mitigate the damaging effects of TAA on the liver and brain, suggesting that oregano could be an excellent alternative in supporting liver health and function.
Read More
User Reviews
USERS' SCORE
Good
Based on 6 Reviews
8.1
- All Reviews
- Positive Reviews
- Negative Reviews
9
Restores bilirubin levels
7 people found this helpful
Oregano oil is a natural antibiotic with anti-inflammatory, antiviral, and antibacterial benefits. Regular consumption promotes liver cell regeneration. After three months of taking it alongside sunflower lecithin, my bilirubin levels returned to normal. I highly recommend this product!
Read More
6
Alleviates SIBO symptoms
4 people found this helpful
Oregano oil has significantly helped with my SIBO and discomfort from excess intestinal gas. Initially, it caused slight dizziness and headaches, which I understand is due to toxins being eliminated from the body. To aid this, I took NAC and silymarin to support liver function. This combination worked wonders for me!
Read More
7.5
Supports cold relief
3 people found this helpful
These oregano oil capsules are fantastic! They help prevent colds and have alleviated my dermagraphism by supporting liver health. I appreciate the enteric coating and the reasonable price.
Read More
7.5
Supports liver function
2 people found this helpful
Oregano oil contains numerous volatile compounds that grant it unique properties. It is traditionally used to bolster the immune system and maintain healthy intestinal flora. With regular use, liver cells are restored, bile secretion is stimulated, digestion improves, and gastrointestinal function normalises. It eradicates various worm infestations and acts as an antibiotic against staphylococcus. I recommend taking 1 capsule three times a day during meals.
Read More
6
Health improvement noted
3 people found this helpful
Quality oil used for the prevention of parasitosis (giardiasis, ascariasis) and fungi in treating atopic dermatitis. It forms part of a comprehensive programme with cat's claw, black walnut, and liver support. My state of health has improved, and I have managed to cope without chemical treatments.
Read More
Frequently Asked Questions
9
Restores bilirubin levels
7 people found this helpful
Oregano oil is a natural antibiotic with anti-inflammatory, antiviral, and antibacterial benefits. Regular consumption promotes liver cell regeneration. After three months of taking it alongside sunflower lecithin, my bilirubin levels returned to normal. I highly recommend this product!
6
Health improvement noted
3 people found this helpful
Quality oil used for the prevention of parasitosis (giardiasis, ascariasis) and fungi in treating atopic dermatitis. It forms part of a comprehensive programme with cat's claw, black walnut, and liver support. My state of health has improved, and I have managed to cope without chemical treatments.
6
Alleviates SIBO symptoms
4 people found this helpful
Oregano oil has significantly helped with my SIBO and discomfort from excess intestinal gas. Initially, it caused slight dizziness and headaches, which I understand is due to toxins being eliminated from the body. To aid this, I took NAC and silymarin to support liver function. This combination worked wonders for me!
7.5
Supports cold relief
3 people found this helpful
These oregano oil capsules are fantastic! They help prevent colds and have alleviated my dermagraphism by supporting liver health. I appreciate the enteric coating and the reasonable price.
7.5
Supports liver function
2 people found this helpful
Oregano oil contains numerous volatile compounds that grant it unique properties. It is traditionally used to bolster the immune system and maintain healthy intestinal flora. With regular use, liver cells are restored, bile secretion is stimulated, digestion improves, and gastrointestinal function normalises. It eradicates various worm infestations and acts as an antibiotic against staphylococcus. I recommend taking 1 capsule three times a day during meals.
9
We evaluated how oregano seed extract, specifically its ethyl acetate fraction, affects liver health in mice that were fed a high-fat diet. Over a period of 10 weeks, we found that when these mice were given 100 mg/kg of oregano seed extract alongside their high-fat diet, their weight and various liver enzyme levels significantly improved.
Remarkably, we observed a reduction in harmful substances like cholesterol and triglycerides, alongside an increase in beneficial high-density lipoprotein. This indicates a positive shift in the mice's overall liver health. Additionally, the fat accumulation in the liver decreased notably, which is a key factor in non-alcoholic fatty liver disease.
Furthermore, we examined the expression of certain genes related to fat metabolism and discovered that their activity went down significantly in the mice that received oregano treatment. This suggests that oregano may help regulate how the body processes fats, potentially leading to better management of obesity and fat-related liver issues.
Remarkably, we observed a reduction in harmful substances like cholesterol and triglycerides, alongside an increase in beneficial high-density lipoprotein. This indicates a positive shift in the mice's overall liver health. Additionally, the fat accumulation in the liver decreased notably, which is a key factor in non-alcoholic fatty liver disease.
Furthermore, we examined the expression of certain genes related to fat metabolism and discovered that their activity went down significantly in the mice that received oregano treatment. This suggests that oregano may help regulate how the body processes fats, potentially leading to better management of obesity and fat-related liver issues.
8
Oregano oil's protective liver effects
We explored how oregano oil, specifically Origanum minutiflorum, could protect the liver from damage caused by carbon tetrachloride (CCl). In our study, we used two doses of oregano oil: a lower dose of 20 mg/kg and a higher dose of 60 mg/kg, over a period of two weeks.
CCl is known for causing severe liver injury, leading to problems like reduced protein synthesis and hematological disorders, such as changes in red and white blood cell counts. Our findings revealed that both doses of oregano oil provided protective effects on the liver. We observed improvements in protein synthesis and liver function markers, while also noting a reduction in the cytogenetic changes that typically occur in liver cells following CCl exposure.
Interestingly, the high dose of oregano oil was particularly effective in protecting red blood cells, though its impact on hemoglobin production was less pronounced. We also noticed that while the higher dose helped reduce white blood cell and lymphocyte counts, this could potentially weaken the immune response. However, it showed improved efficacy against thrombocytosis, or increased platelet aggregation.
Overall, our study suggests that oregano oil may serve as a beneficial treatment option for liver injury, balancing its protective benefits against some potential downsides associated with higher doses.
CCl is known for causing severe liver injury, leading to problems like reduced protein synthesis and hematological disorders, such as changes in red and white blood cell counts. Our findings revealed that both doses of oregano oil provided protective effects on the liver. We observed improvements in protein synthesis and liver function markers, while also noting a reduction in the cytogenetic changes that typically occur in liver cells following CCl exposure.
Interestingly, the high dose of oregano oil was particularly effective in protecting red blood cells, though its impact on hemoglobin production was less pronounced. We also noticed that while the higher dose helped reduce white blood cell and lymphocyte counts, this could potentially weaken the immune response. However, it showed improved efficacy against thrombocytosis, or increased platelet aggregation.
Overall, our study suggests that oregano oil may serve as a beneficial treatment option for liver injury, balancing its protective benefits against some potential downsides associated with higher doses.
9.5
We evaluated the protective effects of oregano (Origanum vulgare) on liver toxicity induced by cyclophosphamide, a commonly used chemotherapy drug known for its potential liver damage. In our study, we pre-treated mice with various doses of oregano extract for seven days before administering a chemotherapy dose.
After 24 hours, we collected blood samples and liver tissues from the animals to assess the liver's response. The results were promising: we found that serum markers indicating liver damage, such as ALT, AST, and ALP, were significantly elevated in the mice treated with cyclophosphamide alone. However, those receiving oregano extract showed a marked reduction in these markers, suggesting that oregano may help protect the liver from poisoning caused by chemotherapy.
The histological examinations aligned with these findings and confirmed that oregano extract has protective properties against liver damage. With its rich array of flavonoids and phenolic compounds, oregano seems capable of supporting liver health during challenging treatments. Thus, incorporating oregano may offer a supportive approach to mitigate the side effects of chemotherapy on the liver.
After 24 hours, we collected blood samples and liver tissues from the animals to assess the liver's response. The results were promising: we found that serum markers indicating liver damage, such as ALT, AST, and ALP, were significantly elevated in the mice treated with cyclophosphamide alone. However, those receiving oregano extract showed a marked reduction in these markers, suggesting that oregano may help protect the liver from poisoning caused by chemotherapy.
The histological examinations aligned with these findings and confirmed that oregano extract has protective properties against liver damage. With its rich array of flavonoids and phenolic compounds, oregano seems capable of supporting liver health during challenging treatments. Thus, incorporating oregano may offer a supportive approach to mitigate the side effects of chemotherapy on the liver.
We aimed to understand how oregano, specifically Origanum vulgare essential oil (OVEO), might protect common carp from liver damage caused by cypermethrin, a harmful pesticide. Our study involved feeding groups of fish different diets, with some receiving OVEO and others being exposed to cypermethrin.
Over a 30-day period, we tracked various health indicators, including liver enzyme levels and signs of oxidative stress. Interestingly, we found that fish exposed to cypermethrin exhibited significant liver and kidney toxicity, which was indicated by increased levels of certain enzymes and reduced antioxidant activity.
However, in fish that were given diets supplemented with OVEO, we observed a remarkable reduction in these negative effects. The essential oil appeared to help restore normal enzyme levels and reduce signs of tissue damage and DNA damage. Overall, this suggests that OVEO could beneficially support liver health in the face of toxic challenges.
Over a 30-day period, we tracked various health indicators, including liver enzyme levels and signs of oxidative stress. Interestingly, we found that fish exposed to cypermethrin exhibited significant liver and kidney toxicity, which was indicated by increased levels of certain enzymes and reduced antioxidant activity.
However, in fish that were given diets supplemented with OVEO, we observed a remarkable reduction in these negative effects. The essential oil appeared to help restore normal enzyme levels and reduce signs of tissue damage and DNA damage. Overall, this suggests that OVEO could beneficially support liver health in the face of toxic challenges.
9
We explored the effects of a natural flavone, didymin, derived from oregano (Origanum vulgare), on liver health. Our research aimed to understand how didymin can help prevent liver damage, specifically in cases induced by carbon tetrachloride (CCl), a commonly used chemical that can harm the liver.
In our study, we found that didymin significantly reduced indicators of liver injury in mice, including levels of important liver enzymes like ALT and AST. Furthermore, treatment with didymin led to lower levels of toxic substances and inflammatory markers in the liver, while boosting the activity of antioxidant enzymes that protect the liver from damage.
We also observed that didymin effectively inhibited key signaling pathways involved in inflammation, specifically the NF-κB and MAPK pathways. Impressively, didymin increased the expression of a protein known as RKIP, which plays a critical role in protecting liver cells. It was interesting to note that when we inhibited RKIP specifically, the protective effects of didymin were diminished.
Overall, our findings suggest that didymin from oregano holds promise in alleviating liver injury, primarily through its antioxidant properties and its ability to regulate inflammatory responses in the liver.
In our study, we found that didymin significantly reduced indicators of liver injury in mice, including levels of important liver enzymes like ALT and AST. Furthermore, treatment with didymin led to lower levels of toxic substances and inflammatory markers in the liver, while boosting the activity of antioxidant enzymes that protect the liver from damage.
We also observed that didymin effectively inhibited key signaling pathways involved in inflammation, specifically the NF-κB and MAPK pathways. Impressively, didymin increased the expression of a protein known as RKIP, which plays a critical role in protecting liver cells. It was interesting to note that when we inhibited RKIP specifically, the protective effects of didymin were diminished.
Overall, our findings suggest that didymin from oregano holds promise in alleviating liver injury, primarily through its antioxidant properties and its ability to regulate inflammatory responses in the liver.
References
- Lee HJ, Bae JY, Park KW, Kim MJ. Ethyl acetate fraction of oregano seed protects non-alcoholic fatty liver in high-fat diet-induced obese mice through modulation of . Food Sci Nutr. 2024;12:2578. 10.1002/fsn3.3939
- Suljević D, Fočak M, Škrijelj R, Mitrašinović-Brulić M. Therapeutic benefit of oregano oil in the acute idiosyncratic hepatotoxicity induced by carbon tetrachloride in rats: Adverse effects of high dose of oreganum. Cell Biochem Funct. 2024;42:e4015. 10.1002/cbf.4015
- Machado M, Nora L, Zanin TBN, Bissacotti BF, Morsch VM, et al. Impacts of intake of trichothecenes (Fusarium sporotrichioides) for dairy calves: Effects on animal growth, oxidative and inflammatory response. Microb Pathog. 2024;190:106605. 10.1016/j.micpath.2024.106605
- Abdelghffar EAR, El-Nashar HAS, Fayez S, Obaid WA, Eldahshan OA. Ameliorative effect of oregano (Origanum vulgare) versus silymarin in experimentally induced hepatic encephalopathy. Sci Rep. 2022;12:17854. 10.1038/s41598-022-20412-3
- Bajagai YS, Radovanovic A, Steel JC, Stanley D. The Effects of Continual Consumption of on Liver Transcriptomics. Animals (Basel). 2021;11. 10.3390/ani11020398
- Khafaga AF, Naiel MAE, Dawood MAO, Abdel-Latif HMR. Dietary Origanum vulgare essential oil attenuates cypermethrin-induced biochemical changes, oxidative stress, histopathological alterations, apoptosis, and reduces DNA damage in Common carp (Cyprinus carpio). Aquat Toxicol. 2020;228:105624. 10.1016/j.aquatox.2020.105624
- Pasavei AG, Mohebbati R, Boroumand N, Ghorbani A, Hosseini A, et al. Anti-Hypolipidemic and Anti-Oxidative Effects of Hydroalcoholic Extract of on the Hepatosteatosis Induced with High-Fat Diet in Rats. Malays J Med Sci. 2020;27:57. 10.21315/mjms2020.27.1.6
- Oniga I, Pușcaș C, Silaghi-Dumitrescu R, Olah NK, Sevastre B, et al. ssp. : Chemical Composition and Biological Studies. Molecules. 2018;23. 10.3390/molecules23082077
- Aralbaeva AN, Mamataeva AT, Zhaparkulova NI, Utegalieva RS, Khanin M, et al. A composition of medicinal plants with an enhanced ability to suppress microsomal lipid peroxidation and a protective activity against carbon tetrachloride-induced hepatotoxicity. Biomed Pharmacother. 2017;96:1283. 10.1016/j.biopha.2017.11.085
- Huang Q, Bai F, Nie J, Lu S, Lu C, et al. Didymin ameliorates hepatic injury through inhibition of MAPK and NF-κB pathways by up-regulating RKIP expression. Int Immunopharmacol. 2017;42:130. 10.1016/j.intimp.2016.11.028
- Wei J, Huang Q, Bai F, Lin J, Nie J, et al. Didymin induces apoptosis through mitochondrial dysfunction and up-regulation of RKIP in human hepatoma cells. Chem Biol Interact. 2017;261:118. 10.1016/j.cbi.2016.11.026
- Fathy SA, Emam MA, Abo Agwa SH, Abu Zahra FA, Youssef FS, et al. The antiproliferative effect of Origanum majorana on human hepatocarcinoma cell line: suppression of NF-κB. Cell Mol Biol (Noisy-le-grand). 2016;62:80.
- Aristatile B, Al-Assaf AH, Pugalendi KV. Carvacrol ameliorates the PPAR-A and cytochrome P450 expression on D-galactosamine induced hepatotoxicity rats. Afr J Tradit Complement Altern Med. 2014;11:118.
- Habibi E, Shokrzadeh M, Chabra A, Naghshvar F, Keshavarz-Maleki R, et al. Protective effects of Origanum vulgare ethanol extract against cyclophosphamide-induced liver toxicity in mice. Pharm Biol. 2015;53:10. 10.3109/13880209.2014.908399
- Sikander M, Malik S, Parveen K, Ahmad M, Yadav D, et al. Hepatoprotective effect of Origanum vulgare in Wistar rats against carbon tetrachloride-induced hepatotoxicity. Protoplasma. 2013;250:483. 10.1007/s00709-012-0431-5
- Shati AA. Effects of Origanum majorana L. on cadmium induced hepatotoxicity and nephrotoxicity in albino rats. Saudi Med J. 2011;32:797.
